The use of placebo in clinical trials has been repeatedly challenged as being unacceptable from an ethical point of view. The present paper responds to this criticism by taking up the issue in the light of the pertinent provisions of the Helsinki Declaration. Examples from different therapeutic areas are given that highlight the importance of placebo in situations in which its use is acceptable according to the Declaration. Particular emphasis is given to the question of active control trials, which, under (...) conditions of low assay sensitivity, may become an ethically less acceptable approach than the use of a placebo control. (shrink)

This specimen of a forthcoming book on the void in ancient natural philosophy by using an example illustrates the problems that confront the scholar. The term εὐτονία, used by Chrysippus, occurs in the Pneumatics of Hero of Alexandria in connection with empty pores. Has he borrowed the notion from Stoic philosophy, or was Strato of Lampsacus, older than Chrysippus, the first to use it? In all probability it was Ctesibius who independently of Stoic philosophy applied the term to account for (...) the kinetic qualities of the material used for his inventions, and Philo Byzantius took over the notion from him. Hero may have derived it from Ctesibius either directly or via Philo. (shrink)

The ancients were interested in the questions of what love really is, why it exists, and how it is experienced. This book presents the best examples, from Homer to Apuleius, interpreted and analyzed by the author. Through an examination of these selections from Greek and Latin literature, some main themes are revealed: success in love with the help of a god; the pursuit of happiness, unity, and completeness; love and beauty; love as an illness, wound, or suffering; betrayal in love, (...) adultery, murder, and death; love as the creating force of the world; the existence of friendship; the basis of parental love; the meaning of love for oneself; the basis and the results of the gods' love for humans. Also included is a comparison of ancient ideas of love with those in later literature and our own ideas about love today. (shrink)

Die Abhandlung weist auf, dass bestimmte Elemente des modernen Bildes der Griechen in Deutschland Konstruktionen im Sinn von Gegenbildentwürfen zur Gegenwart sind. Diese wurden in Zeiten herrschenden Krisenbewusstseins entwickelt, am Ende des 18. Jahrhunderts sowie vom Ende des 19. und im ersten Drittel des 20. Jahrhunderts, und sie sind bis heute virulent. Die Opposition von Gegenwart und griechischer Antike ist von der expliziten oder impliziten Gegenüberstellung der Metaphern 'Kreis und Gerade' bestimmt und betrifft die Literatur, die Zeit- und die Geschichtsvorstellung (...) der Griechen. Kreis und Gerade stehen für Vollkommenheit - Unvollkommenheit, Geschlossenheit - Offenheit, Form - Formlosigkeit, Mittelpunkt - Fehlen eines Mittelpunkts, Endlichkeit - Unendlichkeit, Statik - Dynamik, Sein - Werden. Diese Nachweise exponiert ein Blick auf die Verlusterfahrungen der Neuzeit (Kugelgestalt des Kosmos, Kreisform der Bahnen der Himmelskörper)."--Back cover. (shrink)

The article presents the results of an interview in a student’s group on the problem of the fall into sin based on the discussion at the seminar of Dante's «divine Comedy». The authors consider human as an image and likeness of God, who creates himself, choosing between good and harm. There were changes in the perception of the structure of Inferno: the number of circles of hell in the minds of young people interviewed decreased: all respondents do not see sin (...) in unbelief, three-quarters of respondents − in gluttony, half − in lust. The inter-pretation of heresy and fraud as ways to promote their projects is relevant. The effect of absolute rejection of violence, contemptuous attitude to treachery is revealed. The authors believe that secularization has touched only the first five circles of Hell, but at the bottom everything is still the same. (shrink)

The problem of the Rota Aristotelis deals with the unrolling of two tightly connected concentric circles with different radii. It is to be found in Chapter 24 of the text Mechanica of the Aristotelian corpus (today generally no longer attributed to Aristotle) and has bothered many authors until the modern age. All these scholars agree that the solution given there is not satisfactory. We conclude that Chapter 24 is close to Aristotle, at least, both from a philological and philosophical point (...) of view. The solution of the problem given in the ancient text can very well be transferred into a modern physical phenomenological explanation. (shrink)

The use of placebo in clinical trials has been repeatedly challenged as being unacceptable from an ethical point of view. The present paper responds to this criticism by taking up the issue in the light of the pertinent provisions of the Helsinki Declaration. Examples from different therapeutic areas are given that highlight the importance of placebo in situations in which its use is acceptable according to the Declaration. Particular emphasis is given to the question of active control trials, which, under (...) conditions of low assay sensitivity, may become an ethically less acceptable approach than the use of a placebo control. (shrink)

The Dual State, first published in 1941, remains one of the most erudite books on the legal origins of democracy and dictatorship. It provided the first comprehensive analysis of the rise and nature of National Socialism, and was the only such analysis written from within Hitler's Germany. Fraenkel's concept of the dual state, being the normative state and the the prerogative state. It retains its vital relevance for the theory of democracy in the twenty-first century. The Dual State considerably influenced (...) scholars studying and working on questions of political justice in the period following World War II, particularly in the context of political and legal theory; in the domain of legal history; in the area of constitutional theory; in the context of comparative politics; and in what has become known as the field of comparative constitutional law. This republication of Fraenkel's classic work makes it once again widely available to scholars and students in the field. It includes both Fraenkel's 1974 introduction to the German second edition, never before published in English, and a new introduction by Dr Jens Meierhenrich, examining the world in which The Dual State was originally published, and the lasting legacy of this classic work. (shrink)

This collection of revised and new essays argues that biology is an autonomous science rather than a branch of the physical sciences. Ernst Mayr, widely considered the most eminent evolutionary biologist of the 20th century, offers insights on the history of evolutionary thought, critiques the conditions of philosophy to the science of biology, and comments on several of the major developments in evolutionary theory. Notably, Mayr explains that Darwin's theory of evolution is actually five separate theories, each with its (...) own history, trajectory and impact. Ernst Mayr, commonly referred to as the "Darwin of the 20th century" and listed as one of the top 100 scientists of all-time, is Professor Emeritus at Harvard University. What Makes Biology Unique is the 25th book he has written during his long and prolific career. His recent books include This is Biology: The Science of the Living World (Belknap Press, 1997) and What Evolution Is (Basic Books, 2002). (shrink)

The necessary appearance of Clifford algebras in the quantum description of fermions has prompted us to re-examine the fundamental role played by the quaternion Clifford algebra, C 0,2 . This algebra is essentially the geometric algebra describing the rotational properties of space. Hidden within this algebra are symplectic structures with Heisenberg algebras at their core. This algebra also enables us to define a Poisson algebra of all homogeneous quadratic polynomials on a two-dimensional sub-space, $\mathbb{F}^{a}$ of the Euclidean three-space. This enables (...) us to construct a Poisson Clifford algebra, ℍ F , of a finite dimensional phase space which will carry the dynamics. The quantum dynamics appears as a realisation of ℍ F in terms of a Clifford algebra consisting of Hermitian operators. (shrink)

Cassirer, E. Antropología filosófica.--Vecchio, G. del. El hombre y la naturaleza.--Jaspers, K. La pregunta acerca del hombre.--Marx, K. Existencia y conciencia.--Mounier, E. Las estructuras del universo personal.--Ortega y Gasset, J. Pasado y porvenir para el hombre actual.--Platón. Fedón.--Santayana, G. El nacimiento de la razón. Schaff, A. El marxismo y la filosofía del hombre.--Shorojova, E. V. Lo general humano y lo clasista en la concienia del hombre.--Spear, O. Animal rationale.--Spengler, O. El advenimiento del hombre. Wahl, J. Algunas observaciones acerca del hombre.

What consciousness exactly is remains an unsettled issue among both philosophers and biologists. Three aspects of consciousness are generally recognized: awareness consciousness (through connection...